#Smart transducer

[usocmedical]

Importance of biomedical equipment repairs and maintenance services

Having quality medical equipment and supplies at a hospital is imperative for maintaining a strong and consistent workflow. Right from simpler items like Smart transducer to MRI machines and patient monitors, each and every device used at a hospital must be chosen with a high degree of care. Well-maintained machines and instruments play a major role in streamlining the functioning of a hospital and improving productivity.

[techdriveplay]

ACCENTUM True Wireless delivering the essential Sennheiser sound experience with modern features

Today, Sennheiser introduces the latest addition to its portable lineup, the ACCENTUM True Wireless. This cutting-edge device combines signature Sennheiser acoustics, dynamic wireless capabilities, and an innovative ergonomic design, making it the perfect choice for those with an on-the-go, connected lifestyle. “ACCENTUM True Wireless builds upon the renowned qualities of our over-ear…

[everythingwaschocolateandsugar]

The Smart Materials Market was valued at USD 70.14 billion in 2021 and is predicted to reach USD 251.20 by 2030 with a CAGR of 15.5% from 2022 to 2030.

[govindhtech]

Automatic Identification And Data Capture AIDC Capabilities

Understanding Automatic Identification and Data Capture‘s capabilities, uses, and prospects is essential to remain competitive as firms use data-driven decision-making. This article discusses AIDC’s complexity, essentials, broad variety of usage, and revolutionary impact on modern business operations.

How Automatic Identification and Data Capture (AIDC) Works

Though they are synthesized differently according on the specifics of the processes, each of these technologies uses AIDC in a different manner.

However, usually the gadget uses a transducer to record the data, which includes pictures, sounds, or movies of the target. Converting sound, vision, or video into a digital file is the primary goal of all transducers, regardless of the technology’s application whether it be a bar code, smart card, RFID, or anything else.

After then, the collected data is either automatically moved to a cloud-based system or stored in a database. The software and how it integrates with the collecting equipment, whatever it may be, decide this phase. After that, the data may be evaluated and/or classified.

Despite its broad use, AIDC is primarily utilized for one of three purposes: 1) asset tracking, 2) identification and validation, and 3) connections with other systems.

Components of AIDC

Data Encoding: Alphanumeric characters must be converted into machine-readable code in this first phase. Usually, the encoded data is included into tags, labels, or other carriers that are fastened to the objects that need to be recognized.

Machine reading or scanning: Specialized equipment reads encoded data and generates an electrical signal. These readers might be barcode, RFID, or biometric.

Data decoding: It converts electrical signals into digital data so computers can read and store alphanumeric characters.

Applications of AIDC

Numerous sectors have used Automatic Identification and Data Capture technology due of its versatility:

Retail and Inventory Management: Simplifies point-of-sale procedures and stock monitoring.

Healthcare: Improves hospital asset monitoring, medicine administration, and patient identification.

Supply chain and logistics: Enhances product tracking and streamlines warehouse operations.

Manufacturing: Makes quality control and manufacturing line automation easier.

Access control and security: Offers safe authentication for sensitive data or limited regions.

Automatic Identification and Data Capture greatly lowers human error, boosts productivity, and offers real-time insight into a number of business functions by automating the data gathering process. AIDC systems are become more complex as technology advances, providing increased speed, accuracy, and integration potential with other corporate systems.

Advantages of (AIDC) Automatic Identification and Data Capture

One must first examine the technologies that Automatic Identification and Data Capture enhances before evaluating the advantages of using it.

Barcode readers: AIDC has been producing barcode labels and barcode reader technology for many years. Numerous sectors, including retail, healthcare, education, warehouse environments, manufacturing, entertainment, and many more, may utilize barcodes for monitoring, identification, and counting.

Radio Frequency Identification (RFID): It tags use a scanner to provide detailed information, which is then picked up by a specialized reader via AIDC. RFID tags are usually attached to objects that need real-time reporting and data collecting, as well as sophisticated tracking.

Biometrics: Biometrics compare biological characteristics, such as fingerprints or irises, using a specific AIDC scanning method to identify people. This cutting-edge data capturing technology, which was previously limited to science fiction movies, is now used in workplaces and even on individual mobile devices.

OCR (Optical Character Recognition): It uses data capture and automatic identification to scan text that has been typed or written. This technology is used in the process of digitalization.

Magnetic strips: AIDC is used by magnetic strips to enable the “swiping” of critical data for almost instantaneous verification. The magnetic strips that are used on credit/debit cards, building admission cards, library cards, public transit passes, and other items are part of the AIDC technology that almost everyone carries about at all times.

Smart cards: In essence, smart cards are more sophisticated versions of magnetic strips. They are often used on cards intended just for personal use and in similar ways. The AIDC technology is also used in passports.

Voice recognition: Like biometrics, voice recognition compares a voice to a database of other voices by utilizing a device to record data that is then automatically processed using AIDC technology.

Electronic Article Surveillance (EAS): The technology, articles may be identified as they enter a guarded area like malls or libraries. The technology alerts illegal people from stealing products from stores, libraries, museums, and other essential institutions. This technology allows theft. Electronic Article Surveillance uses RFID and other EAS technologies.

Real-Time Locating Systems (RTLS): It are completely automated systems that use wireless radio frequency to continually monitor and report the whereabouts of monitored resources. It constantly communicates data to a central CPU using low-power radio transmissions. The finding system uses a grid of locating devices spaced 50 to 1000 feet apart to locate RFID tags. RTLS employs battery-operated RFID tags and mobile network-based finding to locate tags.

Sensors: It convert physical quantities into instrument-readable signals. Aerospace, medical, manufacturing, robotics, robots, and automobiles employ sensors. Sensors are crucial to automation and control. New sensors are wireless and use an improved approach to capture more data than wired sensors.

The Challenges of Using Automatic Identification and Data Capture

There is always a risk of data loss, fraud, and/or theft since many of the technologies discussed above include the evaluation and storage of information, some of which is sensitive information.

Let’s examine how Automatic Identification and Data Capture are used specifically with RFID. Although RFID tags may store a lot of data, this does not guarantee that the information is always safe. RFIDs are vulnerable to hacking since they rely on radio waves, which means that anybody with the means to get the valuable data might access this sensitive information.

Additionally, like many modern technologies, Automatic Identification and Data Capture is becoming increasingly sophisticated; nonetheless, a seamless system has yet to be developed, meaning that it does not always function as intended. Fortunately, a wide variety of goods use AIDC technology.

Read more on Govindhtech.com

[atplblog]

Price: [price_with_discount] (as of [price_update_date] - Details) [ad_1] Full immersion for all entertainment Smart Soundbar 600 is a Dolby Atmos soundbar that also features proprietary TrueSpace technology and two upward firing transducers to deliver shockingly immersive sound for all your movies, TV shows, and music. TrueSpace elevates it all No matter what you re watching, Bose TrueSpace technology intelligently analyzes signals other than Dolby Atmos, like stereo or 5.1, and upmixes them to create an immersive multi-channel sound experience. Packed with technology The acoustic architecture squeezes 5 speakers (including 2 upward firing) into a small, 27.5 wide soundbar to spread sound across the room: horizontally left and right, forward, and overhead. Wireless soundbar for streaming Wi-Fi, Bluetooth, Apple AirPlay 2, Spotify Connect, and Chromecast built-in compatibility let you stream content anyway you want. Total control Amazon Alexa voice control is built in. Or you can access Works With Google Assistant capabilities with a compatible Google device. There s also the included remote control and the Bose Music app for quick access to your music. [ad_2]

[amrutatbrc1]

Antenna, Transducer Market : Technology Advancements, Industry Insights, Trends And Forecast 2033

The antenna, transducer, and radome global market report 2024 from The Business Research Company provides comprehensive market statistics, including global market size, regional shares, competitor market share, detailed segments, trends, and opportunities. This report offers an in-depth analysis of current and future industry scenarios, delivering a complete perspective for thriving in the industrial automation software market.

Antenna, Transducer, and Radome Market, 2024 report by The Business Research Company offers comprehensive insights into the current state of the market and highlights future growth opportunities.

Market Size - The antenna, transducer, and radome market size has grown strongly in recent years. It will grow from $11.49 billion in 2023 to $12.44 billion in 2024 at a compound annual growth rate (CAGR) of 8.2%.The growth in the historic period can be attributed to telecommunication expansion, advancements in radar systems, wireless connectivity proliferation, satellite communication development, consumer electronics evolution, medical imaging equipment development.

The antenna, transducer, and radome market size is expected to see strong growth in the next few years. It will grow to $16.81 billion in 2028 at a compound annual growth rate (CAGR) of 7.8%.The growth in the forecast period can be attributed to emergence of smart cities, space exploration and satellite constellations, aviation communication upgrades, renewable energy infrastructure, advancements in automotive connectivity, development of next-gen radar systems. Major trends in the forecast period include integration of antennas in smart devices, growth in automotive antenna technologies, use of multiple-input multiple-output (mimo) antennas, rise of satellite communication antennas, advancements in radar technologies, demand for 3d printed antennas and radomes.

Order your report now for swift delivery @ https://www.thebusinessresearchcompany.com/report/antenna-transducer-and-radome-global-market-report

The Business Research Company's reports encompass a wide range of information, including:

1. Market Size (Historic and Forecast): Analysis of the market's historical performance and projections for future growth.

2. Drivers: Examination of the key factors propelling market growth.

3. Trends: Identification of emerging trends and patterns shaping the market landscape.

4. Key Segments: Breakdown of the market into its primary segments and their respective performance.

5. Focus Regions and Geographies: Insight into the most critical regions and geographical areas influencing the market.

6. Macro Economic Factors: Assessment of broader economic elements impacting the market.

Market Drivers - Rising defense expenditure is expected to propel the growth of the antenna, transducer, and radome market going forward. Defense expenditure includes current and capital expenditures on the armed forces, including peacekeeping troops, defence ministries, and other government agencies involved in defence programs. Defense expenditure helps in the purchase of antenna, transducers, and radome by spending the amount on aircraft, ships and submarines, guided missiles, engines, and components. For instance, according to Stockholm International Peace Research Institute, a Sweden-based independent resource on global security, total global military expenditure increased by 0.7% and reached $2,113 billion in 2021. Therefore, rising defense expenditure is driving the antenna, transducer, and radome market growth.

Market Trends - The development of radome designs is a key trend gaining popularity in the antenna, transducer, and radome market. Research and development in radome consistently come up with new radome designs that provide more and more convenient options. For instance, in November 2021, Rohde & Schwarz GmbH & Co. KG, a Germany-based company operating in the antenna, transducer, and radome market launched an innovative radome tester, the R&S QAR50, an ideal solution for measuring radomes and bumpers in production. This innovative radome design provides accurate and reproducible results that ensure short measurement times with an attractive performance ratio. This also provides a highly modular software concept that allows the tester to be adapted to individual requirements.

The antenna, transducer, and radome market covered in this report is segmented –

1) By Product Type: Antenna and Transducers, Radome 2) By Platform: Airborne, Ground, Naval 3) By Technology: Communication, Radar, Sonar 4) By End User: Commercial, Defense

Get an inside scoop of the antenna, transducer, and radome market, Request now for Sample Report @ https://www.thebusinessresearchcompany.com/sample.aspx?id=7989&type=smp

Regional Insights - North America was the largest region in the antenna, transducer, and radome market in 2023. Asia-Pacific is expected to be the fastest-growing region in the antenna, transducer, and radome market report during the forecast period. The regions covered in the antenna, transducer, and radome market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.

Key Companies - Major companies operating in the antenna, transducer, and radome market report are L3Harris Technologies Inc., Cobham Limited, Raytheon Technologies, Lockheed Martin Corporation, General Dynamics Mission Systems Inc., Northrop Grumman Corporation, Honeywell International Inc., Astronics Corporation, BAE Systems, Thales Group, The NORDAM group, CPI International Inc., Pacific Radomes Inc., Airbus, Harbin Topfrp Composite Co. Ltd, Saab Group., Kratos Defense & Security Solutions Inc., Qorvo Inc., Esterline Technologies Corporation, Terma A/S, RADA Electronic Industries Ltd., Comtech Telecommunications Corp., Rohde & Schwarz GmbH & Co. KG, Diehl Defence., Cobham Advanced Electronic Solutions, Ultra Electronics Holdings plc, Mercury Systems Inc., Antenna Products Corporation, Rantec Microwave Systems, TCI International Inc.

Table of Contents 1. Executive Summary 2. Antenna, Transducer, and Radome Market Report Structure 3. Antenna, Transducer, and Radome Market Trends And Strategies 4. Antenna, Transducer, and Radome Market – Macro Economic Scenario 5. Antenna, Transducer, and Radome Market Size And Growth ….. 27. Antenna, Transducer, and Radome Market Competitor Landscape And Company Profiles 28. Key Mergers And Acquisitions 29. Future Outlook and Potential Analysis 30. Appendix

Contact Us:

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[hospitality-product-directory]

Navigating the World of CTG Machines: A Comprehensive Guide to Suppliers, Benefits, and Best Practices

A CTG (Cardiotocography) machine is a critical tool used in obstetric medicine to monitor fetal heart rates and uterine contractions during labor and delivery. These machines provide real-time data to help healthcare professionals make informed decisions and ensure the best possible outcomes for both the mother and baby.

CTG machines are designed to be user-friendly, with features like dual-channel monitoring, high-resolution displays, alarm systems, portability, data storage and analysis, and wireless connectivity. These features allow for continuous monitoring, remote access, and detailed record-keeping, which are essential for effective patient care.

Benefits of CTG Machines

The use of CTG machines offers numerous benefits for both patients and healthcare providers:

1. Ensuring better outcomes for the mother: CTG machines monitor the strength of contractions in the uterus during childbirth, providing valuable information to the healthcare team.

2. Making smart decisions: By providing real-time data, CTG machines enable healthcare professionals to make more informed and rational clinical decisions.

3. Keeping records and evaluating: CTG machines store data for trend analysis and detailed reporting, allowing for better patient treatment and identifying areas for future improvement.

Top CTG Machine Manufacturers in India

India is home to several reputable CTG machine manufacturers, including:

1. Apple Automation and Sensor (Mumbai)

2. Technocare Medisystems (Surat)

3. Devesh Meditech (Delhi)

4. Korrida Medical Systems (Surat)

5. Mbs India (Muradnagar)

6. Calyx Biotech (Delhi)

7. Advin Health Care (Ahmedabad)

8. Shalvi Engineering Corporation (Navi Mumbai)

9. Sri Indra Diagnostics (Secunderabad)

10. Aoratas Technica Engineering Private Limited (Delhi)

These manufacturers offer a wide range of CTG machines with varying features and price points, catering to the diverse needs of the medical sector.

Maintenance and Usage of CTG Machines

Proper maintenance and usage of CTG machines are crucial for ensuring accurate readings and prolonging their lifespan. Key maintenance practices include:

- Routine calibration: Regular calibration as instructed by the manufacturer is essential for obtaining precise readings.

- Cleaning: Transducers and leads should be cleaned after each use to prevent contamination and maintain cleanliness.

- Software updates: Keeping the machine's software up to date ensures the latest features and security fixes.

- Battery checks: For portable models, regular battery checks are necessary to prevent issues.

- Professional servicing: Annual checks by qualified technicians, including repair work, if necessary, are recommended.

Using a CTG machine involves positioning the patient, applying the transducers, and monitoring the readings. Healthcare professionals should be trained in the proper usage of these machines to ensure accurate results and patient safety.

Conclusion

CTG machines are essential tools in obstetric medicine, providing valuable data to healthcare professionals and ensuring better outcomes for mothers and babies. With a growing demand for these machines, the CTG machine market in India is thriving, with several reputable manufacturers offering high-quality products at competitive prices.

By maintaining and using these machines properly, healthcare providers can maximize their effectiveness and provide the best possible care to their patients. As technology continues to advance, we can expect to see even more innovative and user-friendly CTG machines in the future, further improving patient outcomes and streamlining healthcare processes.

[thesonarshield]

Protect Your Garmin LiveScope LVS34: The Ultimate Guide to Sonar Shield Transducer Covers & Visors

Enhance Your Garmin LiveScope LVS34 with Sonar Shield Transducer Covers & Visors

Garmin LiveScope LVS34 is a revolutionary tool for anglers, providing real-time, detailed underwater images. However, like all advanced electronics, it's vulnerable to environmental factors such as water, debris, and impact damage. The Sonar Shield Transducer Covers & Visors are designed to protect your Garmin LiveScope LVS34, ensuring that your equipment remains in top condition for the long haul.

Why You Need a Sonar Shield for Your Garmin LiveScope LVS34

Protecting your investment in high-end marine electronics is crucial. The Sonar Shield Transducer Covers & Visors are built from heavy-duty materials, offering robust protection against potential hazards. Whether you're navigating through rough waters or docking, these covers safeguard your transducer from impacts, scratches, and the elements.

In addition to protection, Sonar Shield Visors reduce glare on your screen, ensuring clearer visibility and more accurate readings, especially in bright sunlight. This means you can fish with greater precision and confidence, knowing your Garmin LiveScope LVS34 is performing at its best.

Features of Sonar Shield Transducer Covers & Visors

Heavy-Duty Construction: Built to withstand harsh marine environments, these covers are durable and long-lasting.

Impact Protection: Designed to protect against accidental bumps and scrapes.

Glare Reduction: The visor helps reduce screen glare, providing better visibility in bright conditions.

Easy Installation: Sonar Shield products are easy to install, making it convenient for any angler to enhance their equipment.

Conclusion: Secure Your Garmin LiveScope LVS34 with Sonar Shield

For those serious about fishing, protecting your Garmin LiveScope LVS34 with Sonar Shield Transducer Covers & Visors is a smart investment. By providing robust protection and enhanced performance, Sonar Shield ensures that your marine electronics remain reliable and effective, no matter where your fishing adventures take you.

Keywords: Garmin LiveScope protection, Sonar Shield Transducer Covers, Garmin LVS34 Visors, marine electronics protection, heavy-duty transducer covers, glare reduction for Garmin, protect sonar equipment.

[globalgrowthinsights]

Laminated Particle Boards Market Size, Share, Forecast [2032]

Laminated Particle Boards Market provides in-depth analysis of the market state of Laminated Particle Boards manufacturers, including best facts and figures, overview, definition, SWOT analysis, expert opinions, and the most current global developments. The research also calculates market size, price, revenue, cost structure, gross margin, sales, and market share, as well as forecasts and growth rates. The report assists in determining the revenue earned by the selling of this report and technology across different application areas.

Geographically, this report is segmented into several key regions, with sales, revenue, market share and growth Rate of Laminated Particle Boards in these regions till the forecast period

North America

Middle East and Africa

Asia-Pacific

South America

Europe

Key Attentions of Laminated Particle Boards Market Report:

The report offers a comprehensive and broad perspective on the global Laminated Particle Boards Market.

The market statistics represented in different Laminated Particle Boards segments offers complete industry picture.

Market growth drivers, challenges affecting the development of Laminated Particle Boards are analyzed in detail.

The report will help in the analysis of major competitive market scenario, market dynamics of Laminated Particle Boards.

Major stakeholders, key companies Laminated Particle Boards, investment feasibility and new market entrants study is offered.

Development scope of Laminated Particle Boards in each market segment is covered in this report. The macro and micro-economic factors affecting the Laminated Particle Boards Market

Advancement is elaborated in this report. The upstream and downstream components of Laminated Particle Boards and a comprehensive value chain are explained.

Browse More Details On This Report at @https://www.globalgrowthinsights.com/market-reports/laminated-particle-boards-market-100568

 Global Growth Insights

Web: https://www.globalgrowthinsights.com

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[sunaleisocial]

A new way to miniaturize cell production for cancer treatment

New Post has been published on https://sunalei.org/news/a-new-way-to-miniaturize-cell-production-for-cancer-treatment/

A new way to miniaturize cell production for cancer treatment

Researchers from the Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, have developed a novel way to produce clinical doses of viable autologous chimeric antigen receptor (CAR) T-cells in a ultra-small automated closed-system microfluidic chip, roughly the size of a pack of cards. 

This is the first time that a microbioreactor is used to produce autologous cell therapy products. Specifically, the new method was successfully used to manufacture and expand CAR-T cells that are as effective as cells produced using existing systems in a smaller footprint and less space, and using fewer seeding cell numbers and cell manufacturing reagents. This could lead to more efficient and affordable methods of scaling-out autologous cell therapy manufacturing, and could even potentially enable point-of-care manufacturing of CAR T-cells outside of a laboratory setting — such as in hospitals and wards.

CAR T-cell therapy manufacturing requires the isolation, activation, genetic modification, and expansion of a patient’s own T-cells to kill tumor cells upon reinfusion into the patient. Despite how cell therapies have revolutionized cancer immunotherapy, with some of the first patients who received autologous cell therapies in remission for more than 10 years, the manufacturing process for CAR-T cells has remained inconsistent, costly, and time-consuming. It can be prone to contamination, subject to human error, and requires seeding cell numbers that are impractical for smaller-scale CAR T-cell production. These challenges create bottlenecks that restrict both the availability and affordability of these therapies despite their effectiveness.

In a paper titled “A high-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cells” published in the journal Nature Biomedical Engineering, SMART researchers detailed their breakthrough: Human primary T-cells can be activated, transduced, and expanded to high densities in a 2-mililiter automated closed-system microfluidic chip to produce over 60 million CAR T-cells from donors with lymphoma, and over 200 million CAR T-cells from healthy donors. The CAR T-cells produced using the microbioreactor are as effective as those produced using conventional methods, but in a smaller footprint and less space, and with fewer resources. This translates to lower cost of goods manufactured (COGM), and potentially to lower costs for patients.

The groundbreaking research was led by members of the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) interdisciplinary research group at SMART. Collaborators include researchers from the Duke-NUS Medical School; the Institute of Molecular and Cell Biology at the Agency for Science, Technology and Research; KK Women’s and Children’s Hospital; and Singapore General Hospital.

“This advancement in cell therapy manufacturing could ultimately offer a point-of-care platform that could substantially increase the number of CAR T-cell production slots, reducing the wait times and cost of goods of these living medicines — making cell therapy more accessible to the masses. The use of scaled-down bioreactors could also aid process optimization studies, including for different cell therapy products,” says Michael Birnbaum, co-lead principal investigator at SMART CAMP, associate professor of biological engineering at MIT, and a co-senior author of the paper.

With high T-cell expansion rates, similar total T-cell numbers could be attained with a shorter culture period in the microbioreactor (seven to eight days) compared to gas-permeable culture plates (12 days), potentially shortening production times by 30-40 percent. The CAR T-cells from both the microfluidic bioreactor and gas-permeable culture plates only showed subtle differences in cell quality. The cells were equally functional in killing leukemia cells when tested in mice.

“This new method suggests that a dramatic miniaturization of current-generation autologous cell therapy production is feasible, with the potential of significantly alleviating manufacturing limitations of CAR T-cell therapy. Such a miniaturization would lay the foundation for point-of-care manufacturing of CAR T-cells and decrease the “good manufacturing practice” (GMP) footprint required for producing cell therapies — which is one of the primary drivers of COGM,” says Wei-Xiang Sin, research scientist at SMART CAMP and first author of the paper.

Notably, the microbioreactor used in the research is a perfusion-based, automated, closed system with the smallest footprint per dose, smallest culture volume and seeding cell number, as well as the highest cell density and level of process control attainable. These microbioreactors — previously only used for microbial and mammalian cell cultures — were originally developed at MIT and have been advanced to commercial production by Millipore Sigma.

The small starting cell numbers required, compared to existing larger automated manufacturing platforms, means that smaller amounts of isolation beads, activation reagents, and lentiviral vectors are required per production run. In addition, smaller volumes of medium are required (at least tenfold lower than larger automated culture systems) owing to the extremely small culture volume (2 milliliters; approximately 100-fold lower than larger automated culture systems) — which contributes to significant reductions in reagent cost. This could benefit patients, especially pediatric patients who have low or insufficient T-cell numbers to produce therapeutic doses of CAR T-cells.

Moving forward, SMART CAMP is working on further engineering sampling and/or analytical systems around the microbioreactor so that CAR-T production can be performed with reduced labor and out of a laboratory setting, potentially facilitating the decentralized bedside manufacturing of CAR T-cells. SMART CAMP is also looking to further optimize the process parameters and culture conditions to improve cell yield and quality for future clinical use.

The research was conducted by SMART and supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) program.

[jcmarchi]

A new way to miniaturize cell production for cancer treatment

New Post has been published on https://thedigitalinsider.com/a-new-way-to-miniaturize-cell-production-for-cancer-treatment/

A new way to miniaturize cell production for cancer treatment

Researchers from the Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, have developed a novel way to produce clinical doses of viable autologous chimeric antigen receptor (CAR) T-cells in a ultra-small automated closed-system microfluidic chip, roughly the size of a pack of cards. 

This is the first time that a microbioreactor is used to produce autologous cell therapy products. Specifically, the new method was successfully used to manufacture and expand CAR-T cells that are as effective as cells produced using existing systems in a smaller footprint and less space, and using fewer seeding cell numbers and cell manufacturing reagents. This could lead to more efficient and affordable methods of scaling-out autologous cell therapy manufacturing, and could even potentially enable point-of-care manufacturing of CAR T-cells outside of a laboratory setting — such as in hospitals and wards.

CAR T-cell therapy manufacturing requires the isolation, activation, genetic modification, and expansion of a patient’s own T-cells to kill tumor cells upon reinfusion into the patient. Despite how cell therapies have revolutionized cancer immunotherapy, with some of the first patients who received autologous cell therapies in remission for more than 10 years, the manufacturing process for CAR-T cells has remained inconsistent, costly, and time-consuming. It can be prone to contamination, subject to human error, and requires seeding cell numbers that are impractical for smaller-scale CAR T-cell production. These challenges create bottlenecks that restrict both the availability and affordability of these therapies despite their effectiveness.

In a paper titled “A high-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cells” published in the journal Nature Biomedical Engineering, SMART researchers detailed their breakthrough: Human primary T-cells can be activated, transduced, and expanded to high densities in a 2-mililiter automated closed-system microfluidic chip to produce over 60 million CAR T-cells from donors with lymphoma, and over 200 million CAR T-cells from healthy donors. The CAR T-cells produced using the microbioreactor are as effective as those produced using conventional methods, but in a smaller footprint and less space, and with fewer resources. This translates to lower cost of goods manufactured (COGM), and potentially to lower costs for patients.

The groundbreaking research was led by members of the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) interdisciplinary research group at SMART. Collaborators include researchers from the Duke-NUS Medical School; the Institute of Molecular and Cell Biology at the Agency for Science, Technology and Research; KK Women’s and Children’s Hospital; and Singapore General Hospital.

“This advancement in cell therapy manufacturing could ultimately offer a point-of-care platform that could substantially increase the number of CAR T-cell production slots, reducing the wait times and cost of goods of these living medicines — making cell therapy more accessible to the masses. The use of scaled-down bioreactors could also aid process optimization studies, including for different cell therapy products,” says Michael Birnbaum, co-lead principal investigator at SMART CAMP, associate professor of biological engineering at MIT, and a co-senior author of the paper.

With high T-cell expansion rates, similar total T-cell numbers could be attained with a shorter culture period in the microbioreactor (seven to eight days) compared to gas-permeable culture plates (12 days), potentially shortening production times by 30-40 percent. The CAR T-cells from both the microfluidic bioreactor and gas-permeable culture plates only showed subtle differences in cell quality. The cells were equally functional in killing leukemia cells when tested in mice.

“This new method suggests that a dramatic miniaturization of current-generation autologous cell therapy production is feasible, with the potential of significantly alleviating manufacturing limitations of CAR T-cell therapy. Such a miniaturization would lay the foundation for point-of-care manufacturing of CAR T-cells and decrease the “good manufacturing practice” (GMP) footprint required for producing cell therapies — which is one of the primary drivers of COGM,” says Wei-Xiang Sin, research scientist at SMART CAMP and first author of the paper.

Notably, the microbioreactor used in the research is a perfusion-based, automated, closed system with the smallest footprint per dose, smallest culture volume and seeding cell number, as well as the highest cell density and level of process control attainable. These microbioreactors — previously only used for microbial and mammalian cell cultures — were originally developed at MIT and have been advanced to commercial production by Millipore Sigma.

The small starting cell numbers required, compared to existing larger automated manufacturing platforms, means that smaller amounts of isolation beads, activation reagents, and lentiviral vectors are required per production run. In addition, smaller volumes of medium are required (at least tenfold lower than larger automated culture systems) owing to the extremely small culture volume (2 milliliters; approximately 100-fold lower than larger automated culture systems) — which contributes to significant reductions in reagent cost. This could benefit patients, especially pediatric patients who have low or insufficient T-cell numbers to produce therapeutic doses of CAR T-cells.

Moving forward, SMART CAMP is working on further engineering sampling and/or analytical systems around the microbioreactor so that CAR-T production can be performed with reduced labor and out of a laboratory setting, potentially facilitating the decentralized bedside manufacturing of CAR T-cells. SMART CAMP is also looking to further optimize the process parameters and culture conditions to improve cell yield and quality for future clinical use.

The research was conducted by SMART and supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) program.

[usocmedical]

Importance of biomedical equipment repairs and maintenance services

Having quality medical equipment and supplies at a hospital is imperative for maintaining a strong and consistent workflow. Right from simpler items like Smart transducer to MRI machines and patient monitors, each and every device used at a hospital must be chosen with a high degree of care. Well-maintained machines and instruments play a major role in streamlining the functioning of a hospital and improving productivity.

Patients heavily depend on hospitals for their good health and well-being. Hence it becomes important for these facilities to be equipped with all the resources required to efficiently care for the patients.  Broadly speaking, there are two crucial components of hospitals that help it to provide proper care and treatment to the patients, one is the medical staff of the facility and the other is the biomedical supplies present there. Most healthcare facilities need an expansive range of diagnostic, therapeutic, monitoring equipment and more to function in a smooth and seamless manner. Therefore, its staff members must always try to maintain a systematic approach towards biomedical equipment purchase, and invest in Angelus Medical Equipment and other branded items.

The management of a hospital must pay special heed to improving the profitability of health facilities and the reliability of medical equipment used there. They must do proper search when it comes to the selection, purchase, repair and maintenance of medical equipment.

Complete care means functioning equipment

Having medical equipment that is broken or falling into disrepair at a hospital or clinic may hinder the medical staff in providing quality care to the patients. It can lead to long wait times and even cancelled appointments while alternatives are arranged. In many situations, patients might have to travel elsewhere, or find a new medical provider altogether.  Timely services of BMES Equipment Repair would be needed to get things back on track.

The management team of a hospital must also prioritise regular maintenance of medical equipment to make sure that devices are sterilised, safe, and providing proper readouts and reliable indicators of health. Routine maintenance of biomedical equipment can often make catastrophic equipment failure far less likely. It is always a smarter choice to carry out small fixes as issues come up instead of waiting until something breaks badly. The entire process can also save healthcare teams from making expensive emergency maintenance calls for urgent repairs. Details of top providers of biomedical equipment repairs and maintenance services can be found online. 

[pranalipawarshinde]

Voltage Transducer Market Demand, Overview, Size, Trend, and Forecast 2024-2033

“Global Insight Services offers unparalleled market intelligence and strategic consulting services”. to businesses worldwide. Our expertise spans across various industries, including healthcare, technology, and consumer goods, providing comprehensive analysis and actionable insights. By leveraging advanced data analytics and in-depth market research, we empower our clients to make informed decisions, identify growth opportunities, and stay ahead of the competition.

A Voltage Transducer is a device used to convert an electrical signal into another form of energy. It is commonly used to measure the voltage of a power system, to monitor the performance of a system, and to protect a system from overloads. Voltage Transducers are available in a variety of sizes and configurations.

Voltage Transducers are used in a variety of applications, including power systems, industrial automation, automotive electronics, and consumer electronics. They are used to measure the voltage of a power system, to monitor the performance of a system, and to protect a system from overloads. Voltage Transducers are also used in the design and manufacture of electronic devices and systems, such as computers, mobile phones, and other electronic products.

The global Voltage Transducer market is expected to grow at a CAGR of around 7% from 2021 to 2026. The increasing demand for energy-efficient and reliable power systems is driving the growth of this market. The increasing use of electricity in industrial and commercial applications is also driving the growth of the market. In addition, the increasing use of smart devices and the rising demand for renewable energy are expected to drive the demand for Voltage Transducers in the near future.

The major players in the global Voltage Transducer market include ABB, Siemens, Schneider Electric, Honeywell, and General Electric. These companies are focusing on developing innovative products to meet the changing needs of their customers. Furthermore, these companies are expanding their product portfolio to cater to the growing demand in the market.

The increasing demand for Voltage Transducers, along with the growing use of electricity in industrial and commercial applications, is expected to drive the growth of the Voltage Transducer market in the near future. The increasing use of smart devices and the rising demand for renewable energy are also expected to drive the growth of the Voltage Transducer market.

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Electric Motor Market - Forecast(2024 - 2030)

 Electric Motor Market Overview

Electric Motor Market Size is forecast to reach $169 billion by 2030, at a CAGR of 5.6% during 2024-2030. The increase in global electricity consumption and the use of electrical equipment and machines in different industries and the renewables sector are major factors driving the growth in the electric motor market during the forecast period. An increase in awareness of green vehicles among customers has been a key factor leading the market. Besides this, a rising number of government incentives to encourage sales of green vehicles for safeguarding the environment from carbon emissions is analysed to drive the market. The growing interest in sustainable transportation has driven the demand for electric vehicles. Electric motors play a crucial role in powering EVs, and advancements in motor technology contribute to increased efficiency and range. The industrial sector is witnessing the integration of electric motors with the Internet of Things (IoT) and Industry 4.0 technologies. This integration allows for real-time monitoring, predictive maintenance, and improved efficiency in industrial processes.

Smart motor technologies, incorporating features like connectivity, sensors, and advanced control systems, are becoming more prevalent. These innovations contribute to better performance, remote monitoring, and enhanced automation in various applications. Developments in motor control systems, including advanced algorithms and power electronics, contribute to improved motor performance, reduced energy losses, and enhanced control precision. There is an increasing emphasis on developing more energy-efficient electric motors to meet sustainability goals and reduce energy consumption. Regulations and standards promoting energy efficiency also influence the design and manufacturing of electric motors. Additionally, Electric motors have been observing several advancements in technology over the past few years, owing to which its demand is set to gain higher traction during the forecast period 2024-2030.

Report Coverage

The report: “Electric Motor Market Report– Forecast (2024-2030)”, by IndustryARC covers an in-depth analysis of the following segments of the Electric Motor market

By Product Type: AC Motor (Induction Motor, Synchronous Motor, Servo Motor, Stepper Motor), DC Motor (Brushed DC Motor, Brushless DC Motor, Servo Motor, Series Motor, Stepper motor, Compound Motor).

By Product Category: Permanent Magnet, Non-Permanent Magnet.

By Phase: Single Phase, Three Phase.

By Power Rating: Below 0.5W, 0.5W-1W, 1W to 100W, 100W to 1KW, 1KW to 10KW, 10KW and Above.

By Efficiency: IE1, IE2, IE3, IE4.

By Application: Commercial (Automated Doors, Elevators & Escalators, Blowers, Electric Sweepers, Hand Dryers, Data Center & UPS, Pumps, Power Tools, Water Coolers, Camera PTZ Control, Drones, Others), Consumer Products (Pumps, Hair Dryers, Lawn Mowers, Boilers, Dishwashers, Vacuum Cleaners, washing machine, Blenders & Mixers, Fans & Chimneys, Desktop & Laptops, Smartphones, Refrigerators, Others), Automotive (Body Control motors, EPS Motors, Brake Booster BLDC Motor, Seat Adjustment, Belt Tensioner, Car Window Motor, Door Lock Motors, Wiper Motor, Others), Medical & Healthcare (Diagnostic Equipment (CT Scanners, MRI, Biopsy Systems, Diagnostics Analyzers, Ultrasound Transducers, X-Ray, Others), Medical Centrifuges, Medical Pumps, Blowers and Compressors, Surgical Instruments (Saws, Drills, Surgical Robots, Others), Dental CAD/CAM Milling Machines, Exoskeleton & Prosthetics, Microscopes, Wheelchairs & Scooters, Stair Lifts, Hospital Beds & Exam Tables, Others).

By Geography: North America (U.S, Canada, Mexico), South America(Brazil, Argentina and others), Europe(Germany, UK, France, Italy, Spain, Russia, Netherlands, Poland, Czechia, Belgium, Sweden  and Others), APAC(China, Japan India, SK, Aus and Others), and RoW (Middle East and Africa)

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Key Takeaways

• The rising demand for efficient energy usage over concerns of environmental impact of energy generation from conventional sources such as coal and natural gas, is expected to help grow the electric motor market in APAC.

• The DC Motor segment is growing at a significant CAGR of 7.6% in the forecast period 2024-2030. A DC motor consists of a stator and a rotor.

• Medical & Healthcare sector is expected to witness a highest CAGR of 8.5% the forecast period 2024-2030, due to its extensive reliance on electrically powered devices and equipment. Diagnostic imaging equipment, such as MRI and CT scanners, demands high-performance electric motors for precise movements and accurate imaging. 

• Electric Motor companies are strengthening their position through mergers & acquisitions and continuously investing in research and development (R&D) activities to come up with solutions to cater to the changing requirements of customers. 

Electric Motor Market Segment Analysis - By Product Type

The DC Motor segment is expected to grow at a significant CAGR of 7.6% during the forecast period 2024-2030. Owing to the growing penetration of brushless DC motors across various industry verticals substituting brushed dc and even ac induction motors in certain applications such as home appliances. DC motors are used in electric vehicles in the automotive industry for various non-traction applications, contributing to the ongoing shift towards sustainable transportation. As the demand for electric vehicles grows, so does the demand for efficient and dependable DC motors. DC motors are also widely used in industrial automation, powering conveyor systems, robotics, and manufacturing equipment. Owing to the ease of control, they are suitable for accurate and regulated movements in automated processes.

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Electric Motor Market Segment Analysis - By Application

Medical & Healthcare sector is expected to witness a highest growth of CAGR 8.5% during the forecast period 2024-2030, owing to the increase in investments in healthcare and medical sector, along with growing penetration of advanced medical devices & equipment in the sector such as surgical robots, advanced imaging & diagnostic equipment, prosthetics and so on. Medical advances and technical improvements have resulted in the development of a wide range of medical instruments and gear that significantly rely on the precision and efficiency provided by electric motors. High-performance electric motors are required for precise motions and accurate imaging in diagnostic imaging equipment such as MRI and CT scanners. Electric motors provide stability and consistency to patient care and monitoring systems such as infusion pumps and monitoring equipment. Furthermore, the incorporation of electric motors in mobility aids such as electric wheelchairs and patient lifts improves accessibility for people who have mobility issues. Electric motors are used in laboratory equipment, robotic surgical systems, and a variety of medical tools, all of which contribute to the overall efficiency and improvement of healthcare techniques. The demand for electric motors is on the rise as the healthcare industry evolves and adopts more technologically sophisticated solutions, fueling additional innovation in this critical sector.

Electric Motor Market Segment Analysis - By Geography 

Electric Motor market in Asia-Pacific region held significant market share of 38% in 2023. Increasing compliance for energy efficient motors and rising adoption of motor-driven electric vehicles are the key factors driving market growth.  The rising demand for efficient energy usage over concerns of environmental impact of energy generation from conventional sources such as coal and natural gas, is expected to help grow the electric motor market. In addition, advancements in the agriculture sector and enormous investments in industrialization in countries such as China, India, South Korea, and Australia is driving the market growth. Further, the increasing production and sales of electric vehicles in countries including China and Japan is also analyzed to drive the market growth. 

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Electric Motor Market Drivers

Rise in demand for Electric Vehicles

The electric car market has witnessed rapid evolution with the ongoing developments in automotive sector and favorable government policies and support in terms of subsidies and grants, tax rebates. Major manufacturers such as General Motors, Toyota, and BMW plan to release a potential of 400 models and estimated global sales of 25 million by 2025. In 2022, Ford Motor has committed to increase its investments in electric vehicles to $50 billion by 2026, up from a previous spend of $30 billion by 2025. Similarly, in 2020, Volkswagen, Chinese ventures has committed to invest $17.5 billion in electric vehicles by 2025. As electric vehicles use various types of electric motors for traction & auxiliary applications, the rising demand for electric vehicles globally is set to assist the market growth for electric motors used in the same.

Growing R&D activities 

Manufacturers are continuously focusing on R&D to develop new and effective electric motors to meet consumer demand. Increasing concerns, such as environmental pollution and regulations, are forcing manufacturers to develop electric motors that reduce vibration and increase efficiency. For instance, a synchronous electric motor is around 80% more efficient than an induction electric motor. Similarly, the development of a new type of steel for electric motors, which reduces the weight of the electric motor and makes it more efficient and powerful. This new type of electric motor will be small in size and cost effective, which will raise demand from residential and commercial applications. Moreover growing developments from various companies is also analysed to drive the market growth. Hence these factors are analysed to drive the market growth in the forecast period 2024-2030.

Electric Motor Market Challenges 

Easy availability of low-quality electric motors

The market for electric motors is highly fragmented, with a significant number of domestic and international manufacturers. Product quality is a primary parameter for differentiation in this market. The organized sector in the market mainly targets industrial buyers and maintains excellent product quality, while the unorganized sector offers low-cost alternatives to tap local markets. Local manufacturers of electric motors in most countries target the unorganized sector and compete strongly with the global suppliers in the respective markets. Leading market players are currently exposed to intense competition from such unorganized players supplying inexpensive and low-quality electric motors. This acts as a key challenge for the growth of the market.

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Market Landscape

Product launches, acquisitions, Partnerships and R&D activities are key strategies adopted by players in the Electric Motor market. Electric Motor top 10 companies include:

ABB Ltd

Johnson Electric Holdings Limited

Siemens AG

Rockwell Automation

Nidec Corporation

Bosch Electric

Regal Rexnord

Franklin Electric Company Inc.

Teco Electric & Machinery Co. Ltd.

Wolong Electric Group co. ltd.

Acquisitions/Product Launches

• In July 2023, Nidec Corporation announced that it has successfully developed a new electric power steering motor power pack*1 (“EPS-PP”).

• In July 2023, WEG announced new investments for its motor manufacturing plant located in Manaus, Brazil. The Company will invest R$ 48 million, in the next three years, to expand production capacity and adapt the plant to produce a new line of permanent magnet electric motors for split-type air conditioners

• In December 2023, Johnson Electric Launches 48-Volt Cooling Fan Module with High Power and Efficiency. Johnson Electric is pleased to announce the launch of the 48-Volt Cooling Fan Module with power up to 1.5kW to meet the most demanding cooling requirements.  The need to reduce emissions and increase the electrification of the vehicle, requires higher cooling performance and efficiency.

[auto2mation1]

Innovations in Transmitters: Advancing Industrial Automation

In the world of industrial automation, transmitters play a essential role. These devices are the crucial contributor, quietly working to ensure that data is accurately transmitted for monitoring and control purposes. Over the years, innovations in transmitter technology have revolutionized industrial processes, leading to increased efficiency, safety, and reliability. In this blog, we will look into the exciting advancements in transmitters that are shaping the future of industrial automation.

The Evolution of Transmitter Technology

Transmitters have come a long way since their setting up. Initially used for basic signal transmission, they have evolved into sophisticated devices with a wide range of capabilities. Let's explore the key milestones in the evolution of transmitter technology:

Analog to Digital: The shift from analog to digital transmitters marked a significant advancement. Digital transmitters offer higher accuracy, improved reliability, and better compatibility with modern control systems.

Wireless Communication: The introduction of wireless transmitters revolutionized industrial communication. These devices eliminate the need for complex wiring, allowing for flexible and cost-effective installations.

Smart Transmitters: Smart transmitters represent a major leap forward. These devices are equipped with microprocessors and advanced diagnostics, enabling self-calibration, remote monitoring, and predictive maintenance.

Advanced Features and Functionalities

Modern transmitters boast an array of advanced features that enhance their performance and usability. Let's explore some of these key features:

Multivariable Measurement: Transmitters can now measure multiple process variables such as temperature, pressure, and flow rate simultaneously. This consolidation of measurements simplifies installations and reduces equipment costs.

HART Protocol: The Highway Addressable Remote Transducer (HART) protocol enables two-way digital communication with smart transmitters. This allows for configuration, diagnostics, and monitoring of devices remotely.

WirelessHART: Building upon the HART protocol, WirelessHART offers the benefits of wireless communication for industrial applications. It provides reliable data transmission with high security and scalability.

Intrinsically Safe Designs: Safety is dominant in industrial environments. Intrinsically safe transmitters are designed to operate in hazardous areas without risk of causing ignition, making them essential for applications in chemical plants, oil refineries, and more.

 Applications in Diverse Industries

The versatility of transmitters enables their use across a wide range of industries. Let's explore how these innovations are making an impact:

Oil and Gas: In the oil and gas sector, transmitters are used for monitoring wellheads, pipelines, and storage tanks. Advanced features such as remote diagnostics and wireless communication improve operational efficiency and safety.

Chemical Processing: Transmitters play a critical role in chemical processing plants, where precise measurements are crucial. Intrinsically safe designs and smart capabilities enable accurate monitoring of volatile substances.

Power Generation: From traditional power plants to renewable energy facilities, transmitters are vital for monitoring parameters such as steam pressure, water levels, and gas flow. This data ensures optimal performance and maintenance scheduling.

Water and Wastewater: In water treatment facilities, transmitters help monitor water quality, flow rates, and pressure. Wireless transmitters simplify installations in sprawling treatment plants, improving overall efficiency.

Manufacturing: In manufacturing, transmitters are used for process control, ensuring consistent product quality. The integration of IoT allows manufacturers to gather real-time data for predictive maintenance and process optimization.

Future Trends and Innovations

The world of industrial automation is constantly evolving, and transmitters are at the forefront of innovation. Here are some exciting trends shaping the future:

5G Integration: The integration of 5G technology with transmitters will enable ultra-fast and reliable communication. This opens up possibilities for real-time control and monitoring in remote or mobile applications.

Edge Computing: Transmitters equipped with edge computing capabilities can process data locally, reducing latency and dependence on central servers. This is particularly useful for applications where real-time decisions are critical.

Energy Harvesting: Future transmitters may harness ambient energy sources such as vibrations or heat to power them. This reduces the reliance on batteries and enables sustainable, maintenance-free operation.

Conclusion

Innovations in transmitter technology are driving extraordinary advancements in industrial automation. From analog to smart, from wired to wireless, transmitters have undergone a remarkable transformation. These devices are not just tools for measurement; they are enablers of efficiency, safety, and reliability in industrial processes. The journey of transmitters in industrial automation is far from over. With each innovation, they bring us closer to a future where automation is not just efficient but also intelligent and adaptive to the needs of the industry.